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The patient's complex symptoms were attributed to multiple factors, including prolonged physical inactivity, weight gain, and posttraumatic stress associated with personal and emotional traumas

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A meta-analysis of 28 studies with 74,660 patients who had bioprosthetic valves and atrial fibrillation showed that DOACs were more effective in reducing the risks of bleeding, strokes, systemic embolism, and intracranial bleeding when compared to warfarin